Insulin Hormone

Insulin:

Insulin is another important weight loss hormone that can affect your weight. It is produce by the pancreas and helps regulate blood sugar levels in your body. It also sends fatty acids, amino acids and glucose to go to the various cells. After you eat your blood sugar goes up and the pancreas releases more insulin to regulate it.

The downside of insulin is that too much of it can be produced in the body in the effort to maintain blood sugar levels. This is often triggered by a low-protein high-carbohydrate diet. All this can result in you gaining weight and your cells even becoming resistant to losing fat.

Insulin and Its Functions

Insulin is the very first hormone to be identified and isolated in the pure form. It is a protein hormone synthesized by beta cells of the islets of Langerhans of the pancreas. The structure of insulin constitutes 2 polypeptide chains; ‘A’ chain having 21 amino acids and ‘B’ chain having 30 amino acids. Although insulin has a moderate set of functions, the primary function is to trigger and facilitate the glucose absorption by various cells. Glucose is absorbed and stored in cells in the form of glycogen. Other supportive functions include stimulation of glycogen synthesis and inhibition of gluconeogenesis. Insulin also has the overall responsibility of regulating the glucose content in blood and inhibiting fat usage for energy.

Diabetes mellitus is the group of metabolic diseases caused by disorders in the insulin system. Type 1 diabetes is caused by absence of production of insulin whilst Type 2 diabetes is due to the inefficiency of insulin receptors which is termed as insulin resistance. It is widely considered Type 2 diabetes is incited by obesity. However recent studies state the reverse is also substantive. As the insulin receptors are inefficient to consume the level of insulin in blood rises above normal causing hyperglycemia and lead to obesity. Obesity induced by hyperglycemia features storing of fat primarily in the abdomen area counter to storing in hips and thighs.

How Insulin Works?

How to Improve Insulin Resistance?

Insulin resistance can lowered to an extent by lifestyle and dietary controls. The key idea is the efficient use of available insulin receptors by flexing body metabolism. One dietary movement that can be made to establish this is to include whole carbs such as whole grain breads and cereals, whole fruits and vegetables etc. in the diet that are low in fiber. These items get digested quickly than fibrous foods and impact more on the available insulin receptors thus lowering the insulin level. To speed up the metabolism and to balance blood sugar, daily exercise is a must. Stress should be managed as it is a dominant causation of diabetes induced obesity.

What are the medical treatment available?

Diabetes-obesity combination is arguably the most reported health concern in the modern world. Hence is the variety of medical treatments available for diabetes and obesity. The medications include biguanides to improve insulin reception, thiazolidinedione drugs to improve insulin consumption by the cells and alpha-glucosidase inhibitors to lower sugar absorption in the intestine. In some cases, individuals can undergo the expensive bariatric surgery to shed weight. Insulin therapy is only effective for a small number of type 2 diabetes patients.

 

Ref: 

  • Textbook of biochemistry. V.M. Vasudevan
  • http://drhyman.com/blog/2010/05/20/5-steps-to-reversing-type-2-diabetes-and-insulin-resistance/#close
  • http://www.mayoclinic.com/health/type-2-diabetes/DS00585/DSECTION=treatments-and-drugs
  • http://www.ncbi.nlm.nih.gov/pubmed/9457008
  • http://www.heartlandnaturopathic.com/irdiet.htm

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